This work is licensed under a Creative Commons Attribution 4.0 International License.
Buforin II
General Information
DRACP ID DRACP00262
Peptide Name Buforin II
Sequence TRSSRAGLQFPVGRVHRLLRK
Sequence Length 21
UniProt ID P55897 P59890 P0DQL2 C0HJQ3 P06897 P02264 Q7ZUY3 Q96KK5 Q6GM86 P0C0S8 Q99878
PubChem CID Not available
Origin Bufo Bufo Gargarizans
Type Native peptide
Classification
Active ACP Antiangiogenic
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 5% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C106H184N40O26
Absent amino acids CDEIMNWY
Common amino acids R
Mass 279178
Pl 13.1
Basic residues 7
Acidic residues 0
Hydrophobic residues 7
Net charge 7
Boman Index -7021
Hydrophobicity -63.81
Aliphatic Index 88.1
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.