This work is licensed under a Creative Commons Attribution 4.0 International License.
Citropin1.1
General Information
DRACP ID DRACP00263
Peptide Name Citropin1.1
Sequence GLFDVIKKVASVIGGL
Sequence Length 16
UniProt ID P81835
PubChem CID Not available
Origin Australian blue mountains tree frog, Litoria citropa
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 60% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H130N18O20
Absent amino acids CEHMNPQRTWY
Common amino acids GV
Mass 188373
Pl 9.54
Basic residues 2
Acidic residues 1
Hydrophobic residues 9
Net charge 1
Boman Index 1619
Hydrophobicity 128.13
Aliphatic Index 158.13
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.