This work is licensed under a Creative Commons Attribution 4.0 International License.
OmigaNAn MBI-226
General Information
DRACP ID DRACP00265
Peptide Name OmigaNAn MBI-226
Sequence ILRWPWWPWRRK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Helical peptide with a predominance of one or more amino acids tryptophane-rich
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 27% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C90H126N26O13
Absent amino acids ACDEFGHMNQSTVY
Common amino acids W
Mass 197653
Pl 12.81
Basic residues 4
Acidic residues 0
Hydrophobic residues 6
Net charge 4
Boman Index -3115
Hydrophobicity -132.5
Aliphatic Index 65
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 22000
Absorbance 280nm 2000
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.