This work is licensed under a Creative Commons Attribution 4.0 International License.
PexigaNAn MSI-78
General Information
DRACP ID DRACP00266
Peptide Name PexigaNAn MSI-78
Sequence GIGKFLKKAKKFGKAFVKILKK
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Helical peptide with a predominance of one or more amino acids tryptophane-rich
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 75% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C122H209N31O23
Absent amino acids CDEHMNPQRSTWY
Common amino acids K
Mass 285296
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 10
Net charge 9
Boman Index -1085
Hydrophobicity -15.91
Aliphatic Index 93.18
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.