Protegrin 1
General Information
DRACP ID DRACP00267
Peptide Name Protegrin 1
Sequence RGGRLCYCRRRFCVCVGR
Sequence Length 18
UniProt ID P32194
PubChem CID Not available
Origin Alpha helical peptide without cysteines
Type Synthetic peptide
Classification
Active ACP
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 61% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C88H150N36O20S4
Absent amino acids ADEHIKMNPQSTW
Common amino acids R
Mass 246403
Pl 10.92
Basic residues 6
Acidic residues 0
Hydrophobic residues 4
Net charge 6
Boman Index -6574
Hydrophobicity -25
Aliphatic Index 53.89
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1740
Absorbance 280nm 102.35
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available