Protegrin 1

General Information


DRACP ID  DRACP00267

Peptide Name   Protegrin 1

Sequence  RGGRLCYCRRRFCVCVGR

Sequence Length  18

UniProt ID  P32194 

PubChem CID  Not available

Origin  Alpha helical peptide without cysteines

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia Leukemia 61% Cytotoxicity at 0.5 µg/ml MTT assay 6 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  1PG1 

Predicted Structure  DRACP00267

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C88H150N36O20S4

Absent amino acids  ADEHIKMNPQSTW

Common amino acids  R

Mass  246403

Pl  10.92

Basic residues  6

Acidic residues  0

Hydrophobic residues  4

Net charge  6

Boman Index  -6574

Hydrophobicity  -25

Aliphatic Index  53.89

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  1740

Absorbance 280nm  102.35

Polar residues  8

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21403917

Title  Antitumor activity of antimicrobial peptides against U937 histiocytic cell line

Doi Not available

Year  2011

Literature 2

Pubmed ID 8573171

Title  A novel antimicrobial peptide from Bufo bufo gargarizans

Doi 10.1006/bbrc.1996.0071

Year  1996

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.