This work is licensed under a Creative Commons Attribution 4.0 International License.
DI
General Information
DRACP ID DRACP00269
Peptide Name DI
Sequence LTFEHYWAQLTS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin E3 ubiquitin-protein ligase
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides Affect cell cycle
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| -- | -- | -- | IC50 for MDM2=0.29 µM | ELISA assay | Not available | 1 |
| -- | -- | -- | IC50 for MDMX-p53=1.6 µM | ELISA assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism Inhibits MDM2-p53 Interaction
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H98N16O20
Absent amino acids CDGIKMNPRV
Common amino acids LT
Mass 169204
Pl 5.36
Basic residues 1
Acidic residues 1
Hydrophobic residues 5
Net charge 0
Boman Index -873
Hydrophobicity -20
Aliphatic Index 73.33
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 635.45
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21423613
Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction
Doi 10.1371/journal.pone.0017898
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.