This work is licensed under a Creative Commons Attribution 4.0 International License.
P5317-28
General Information
DRACP ID DRACP00271
Peptide Name P5317-28
Sequence QETFSDLWKLLP
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin E3 ubiquitin-protein ligase
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides Affect cell cycle
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| -- | -- | -- | IC50 for MDM2=4.7 µM | ELISA assay | Not available | 1 |
| -- | -- | -- | IC50 for MDMX-p53=30 µM | ELISA assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism Inhibits MDM2-p53 Interaction
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C70H105N15O20
Absent amino acids ACGHIMNRVY
Common amino acids L
Mass 167308
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Net charge -1
Boman Index -1252
Hydrophobicity -35
Aliphatic Index 97.5
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21423613
Title mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction
Doi 10.1371/journal.pone.0017898
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.