This work is licensed under a Creative Commons Attribution 4.0 International License.
Vaby D(4)
General Information
DRACP ID DRACP00280
Peptide Name Vaby D(4)
Sequence GLPVCGETCFGGTCNTPGCTCDPWPVCTRN
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Viola abyssinica of the Ethiopian Highlands
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | IC50=2.6 μM | Fluorometric microculture cytotoxicity assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H194N36O42S6
Absent amino acids AHIKMQSY
Common amino acids C
Mass 360697
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Net charge -1
Boman Index -2589
Hydrophobicity -4.33
Aliphatic Index 32.33
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5875
Absorbance 280nm 202.59
Polar residues 18
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21434649
Title Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.