This work is licensed under a Creative Commons Attribution 4.0 International License.
LTX-318
General Information
DRACP ID DRACP00283
Peptide Name LTX-318
Sequence XXWXXXWWX
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=248 ± 5 µM | MTT assay | 30 min | 1 |
| MT-1 | Human mammary carcinoma | Carcinoma | IC50=216 ± 36 µM | MTT assay | 30 min | 1 |
| Kelly | Neuroblastoma | Blastoma | IC50=78 ± 7 µM | MTT assay | 30 min | 1 |
| A20 | Murine B cell lymphoma | Lymphoma | IC50=21.7 ± 2.5 µM | MTT assay | 4 h | 2 |
| AT84 | Murine squamous cell carcinoma | Carcinoma | IC50=23.0 ± 3.6 µM | MTT assay | 4 h | 2 |
Hemolytic Activity Human red blood cells (RBC): IC50>695 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50> 347 μM; MRC-5: IC50=323 ± 33 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(1/2/5/6/9)=ornithine; X(4)=Dip (Diphenylalanine)
Chiral L
Physicochemical Information
Formula C33H20N6O-2
Absent amino acids ACDEFGHIKLMNPQRSTVY
Common amino acids X
Mass 127143
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 699
Hydrophobicity -30
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 16500
Absorbance 280nm 2062.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21453492
Title Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells
Year 2011
Literature 2
Pubmed ID 26982623
Title Discovery of a 9-mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide
Doi 10.1021/acs.jmedchem.5b02025
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11902
This work is licensed under a Creative Commons Attribution 4.0 International License.