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Cliotides T2, CT2
General Information
DRACP ID DRACP00284
Peptide Name Cliotides T2, CT2
Sequence GEFLKCGESCVQGECYTPGCSCDWPICKKN
Sequence Length 30
UniProt ID G1CWH1
PubChem CID Not available
Origin Clitoria ternatea
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=8.0 μM | MTT assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=7.59 µM | MTT assay | 72 h | 2 |
Hemolytic Activity Human red blood cells: HD50=8.0 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys6<--->Cys20; Cys10<--->Cys22; Cys15<--->Cys27; NCB: Gly1<--->Asn30
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C138H210N36O45S6
Absent amino acids AHMR
Common amino acids C
Mass 380322
Pl 4.59
Basic residues 3
Acidic residues 4
Hydrophobic residues 5
Net charge -1
Boman Index -3686
Hydrophobicity -39
Aliphatic Index 35.67
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 7365
Absorbance 280nm 253.97
Polar residues 15
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21596752
Title Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family
Year 2011
Literature 2
Pubmed ID 23419988
Title Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4275
This work is licensed under a Creative Commons Attribution 4.0 International License.