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Viba 15
General Information
DRACP ID DRACP00295
Peptide Name Viba 15
Sequence GLPVCGETCVGGTCNTPGCACSWPVCTRN
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Viola philippica
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MM96L | Melanoma | Carcinoma | IC50=3.10±0.06µM | MTT assay | 5h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=10.21±0.43µM | MTT assay | 5h | 1 |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1.32±0.15µM | SRB assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HFF-1: IC50=2.38±0.09µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys26.
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C116H185N35O39S6
Absent amino acids DFHIKMQY
Common amino acids C
Mass 338594
Pl 5.94
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -1513
Hydrophobicity 23.79
Aliphatic Index 46.9
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5875
Absorbance 280nm 209.82
Polar residues 18
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21723349
Title Isolation and characterization of cytotoxic cyclotides from Viola philippica
Doi 10.1016/j.peptides.2011.06.016
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4484
This work is licensed under a Creative Commons Attribution 4.0 International License.