NRC-14

General Information


DRACP ID  DRACP00297

Peptide Name   NRC-14

Sequence  AGWGSIFKHIFKAGKFIHGAIQAHND

Sequence Length  26

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia 50% Cell death=8 µg/ml MTT assay 2h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis>256 µg/ml

Normal (non-cancerous) Cytotoxicity  Zebrafish embryos: >10% Killing=5 µM (28, 52hpf embryo); 100% Killing=25 µM (4hpf embryo)

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00297

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C134H196N38O32

Absent amino acids  CELMPRTVY

Common amino acids  AGI

Mass  329740

Pl  10.51

Basic residues  6

Acidic residues  1

Hydrophobic residues  12

Net charge  5

Boman Index  -1298

Hydrophobicity  -5.77

Aliphatic Index  75.38

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  220

Polar residues  6

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21729875

Title  The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents

Doi 10.1242/dmm.007310

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.