This work is licensed under a Creative Commons Attribution 4.0 International License.
NRC-09
General Information
DRACP ID DRACP00298
Peptide Name NRC-09
Sequence FFRLLFHGVHHGGGYLNAA
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death>128 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: No Killing
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C101H141N29O22
Absent amino acids CDEIKMPQSTW
Common amino acids G
Mass 243467
Pl 9.36
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Net charge 4
Boman Index -56
Hydrophobicity 37.37
Aliphatic Index 87.37
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 82.78
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.