This work is licensed under a Creative Commons Attribution 4.0 International License.
NRC-05
General Information
DRACP ID DRACP00300
Peptide Name NRC-05
Sequence FLGALIKGAIHGGRFIHGMIQNHH
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Pseudopleuronectes americanus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death=128 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: >10% Killing=5 µg/ml(4, 52hpf embryo); 100% Killing=25 µg/ml (28hpf embryo)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C120H186N38O27S
Absent amino acids CDEPSTVWY
Common amino acids G
Mass 303556
Pl 11.65
Basic residues 6
Acidic residues 0
Hydrophobic residues 10
Net charge 6
Boman Index -514
Hydrophobicity 27.08
Aliphatic Index 105.83
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.