This work is licensed under a Creative Commons Attribution 4.0 International License.
NRC-15
General Information
DRACP ID DRACP00302
Peptide Name NRC-15
Sequence GFWGKLFKLGLHGIGLLHLHL
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death=64 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=64 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: >10% Killing=1 µg/ml (4hpf embryo); >10% Killing=5 µg/ml (28, 52hpf embryo)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C117H178N30O22
Absent amino acids ACDEMNPQRSTVY
Common amino acids L
Mass 271384
Pl 10.81
Basic residues 5
Acidic residues 0
Hydrophobic residues 11
Net charge 5
Boman Index 2727
Hydrophobicity 78.1
Aliphatic Index 148.57
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 275
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.