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NRC-06
General Information
DRACP ID DRACP00305
Peptide Name NRC-06
Sequence GWGSIFKHGRHAAKHIGHAAVNHYL
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Pseudopleuronectes americanus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death=128 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: 100% Killing=25 µg/ml (4, 28hpf embryo); >10% Killing=5 µg/ml (52hpf embryo)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C127H186N42O29
Absent amino acids CDEMPQT
Common amino acids H
Mass 319343
Pl 10.9
Basic residues 8
Acidic residues 0
Hydrophobic residues 10
Net charge 8
Boman Index -2439
Hydrophobicity -37.6
Aliphatic Index 74.4
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 291.25
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.