This work is licensed under a Creative Commons Attribution 4.0 International License.
NRC-12
General Information
DRACP ID DRACP00306
Peptide Name NRC-12
Sequence GWKKWFNRAKKVGKTVGGLAVDHYL
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death=64 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: >10% Killing=5 µg/ml (4hpf embryo); >10% Killing=25 µg/ml (28hpf embryo); 100% Killing=5 µg/ml (52hpf embryo)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C135H208N38O31
Absent amino acids CEIMPQS
Common amino acids K
Mass 328765
Pl 11.01
Basic residues 7
Acidic residues 1
Hydrophobic residues 10
Net charge 6
Boman Index -2842
Hydrophobicity -52
Aliphatic Index 74
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 12490
Absorbance 280nm 520.42
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.