This work is licensed under a Creative Commons Attribution 4.0 International License.
NRC-08
General Information
DRACP ID DRACP00311
Peptide Name NRC-08
Sequence RSTEDIIKSISGGGFLNAMNA
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 50% Cell death>128 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>256 µg/ml
Normal (non-cancerous) Cytotoxicity Zebrafish embryos: No Killing; HUVEC: 50% Cell death>128 µg/ml; HMEC-1: 50% Cell death>128 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H153N27O32S
Absent amino acids CHPQVWY
Common amino acids GIS
Mass 253837
Pl 6.5
Basic residues 2
Acidic residues 2
Hydrophobic residues 7
Net charge 0
Boman Index -3060
Hydrophobicity -5.24
Aliphatic Index 83.81
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21729875
Title The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.