Transferrin receptor (TfR)-lytic hybrid peptide

General Information


DRACP ID  DRACP00313

Peptide Name   Transferrin receptor (TfR)-lytic hybrid peptide

Sequence  THRPPMWSPVWPGGGKLlLKlLkkLLKlLKKK

Sequence Length  32

UniProt ID  Not available

PubChem CID  Not available

Origin  Transferrin receptor (TfR)

Type  Synthetic peptide

Classification

  

Active ACP Cancer targeted peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
BT-474 Invasive breast carcinoma of no special type Carcinoma IC50=8.8 µM WST-1 assay 72 h 1
T-47D Invasive breast carcinoma of no special type Carcinoma IC50=4.0 µM WST-1 assay 72 h 1
SK-BR-3 Breast adenocarcinoma Carcinoma IC50=6.5 µM WST-1 assay 72 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=7.8 µM WST-1 assay 72 h 1
BT-20 Invasive breast carcinoma of no special type Carcinoma IC50=4.8 µM WST-1 assay 72 h 1
ZR-75-1 Invasive breast carcinoma of no special type Carcinoma IC50=9.3 µM WST-1 assay 72 h 1
SF295 Glioblastoma Blastoma IC50=6.3 µM WST-1 assay 72 h 1
SN19 Glioblastoma Blastoma IC50=7.8 µM WST-1 assay 72 h 1
U-251MG Astrocytoma Carcinoma IC50=7.0 µM WST-1 assay 72 h 1
HuCC-T1 Intrahepatic cholangiocarcinoma; Cholangiocarcinoma Carcinoma IC50=8.3 µM WST-1 assay 72 h 1
LNCaP Prostate carcinoma Carcinoma IC50=6.2 µM WST-1 assay 72 h 1
COLO 587 Colon adenocarcinoma Carcinoma IC50=6.4 µM WST-1 assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Transferrin receptor

Affinity  Not available

Mechanism  Lytic peptide containing cationic-rich amino acids components that disintegrates the cell membrane for the cancer cell killing

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  l=D-Leucine; k=D-Lysine

Chiral  Mix



Physicochemical Information


Formula  C149H236N40O25S

Absent amino acids  ACDEFINQY

Common amino acids  KL

Mass  357294

Pl  12.1

Basic residues  8

Acidic residues  0

Hydrophobic residues  9

Net charge  8

Boman Index  -1546

Hydrophobicity  -40.94

Aliphatic Index  82.19

Half Life 
  /

Extinction Coefficient cystines  11000

Absorbance 280nm  354.84

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 21849092

Title  A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

Doi 10.1186/1471-2407-11-359

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.