This work is licensed under a Creative Commons Attribution 4.0 International License.
Transferrin receptor (TfR)-lytic hybrid peptide
General Information
DRACP ID DRACP00313
Peptide Name Transferrin receptor (TfR)-lytic hybrid peptide
Sequence THRPPMWSPVWPGGGKLlLKlLkkLLKlLKKK
Sequence Length 32
UniProt ID Not available
PubChem CID Not available
Origin Transferrin receptor (TfR)
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BT-474 | Invasive breast carcinoma of no special type | Carcinoma | IC50=8.8 µM | WST-1 assay | 72 h | 1 |
| T-47D | Invasive breast carcinoma of no special type | Carcinoma | IC50=4.0 µM | WST-1 assay | 72 h | 1 |
| SK-BR-3 | Breast adenocarcinoma | Carcinoma | IC50=6.5 µM | WST-1 assay | 72 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=7.8 µM | WST-1 assay | 72 h | 1 |
| BT-20 | Invasive breast carcinoma of no special type | Carcinoma | IC50=4.8 µM | WST-1 assay | 72 h | 1 |
| ZR-75-1 | Invasive breast carcinoma of no special type | Carcinoma | IC50=9.3 µM | WST-1 assay | 72 h | 1 |
| SF295 | Glioblastoma | Blastoma | IC50=6.3 µM | WST-1 assay | 72 h | 1 |
| SN19 | Glioblastoma | Blastoma | IC50=7.8 µM | WST-1 assay | 72 h | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=7.0 µM | WST-1 assay | 72 h | 1 |
| HuCC-T1 | Intrahepatic cholangiocarcinoma; Cholangiocarcinoma | Carcinoma | IC50=8.3 µM | WST-1 assay | 72 h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=6.2 µM | WST-1 assay | 72 h | 1 |
| COLO 587 | Colon adenocarcinoma | Carcinoma | IC50=6.4 µM | WST-1 assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Transferrin receptor
Affinity Not available
Mechanism Lytic peptide containing cationic-rich amino acids components that disintegrates the cell membrane for the cancer cell killing
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C149H236N40O25S
Absent amino acids ACDEFINQY
Common amino acids KL
Mass 357294
Pl 12.1
Basic residues 8
Acidic residues 0
Hydrophobic residues 9
Net charge 8
Boman Index -1546
Hydrophobicity -40.94
Aliphatic Index 82.19
Half Life
/
Extinction Coefficient cystines 11000
Absorbance 280nm 354.84
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21849092
Title A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.