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Brevinin-2DYc
General Information
DRACP ID DRACP00314
Peptide Name Brevinin-2DYc
Sequence GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Rana dybowskii; Rana nigromaculata
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=49.3±7.2 µM | MTT assay | 1h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=50.2±4.6 µM | MTT assay | 1h | 1 |
Hemolytic Activity Human erythrocytes: 2% Hemolysis=100 µg/ml; 50% Hemolysis=65.2±7.6 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys27<--->Cys33
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C147H254N40O42S2
Absent amino acids HIMPRTWY
Common amino acids G
Mass 388899
Pl 9.55
Basic residues 5
Acidic residues 2
Hydrophobic residues 13
Net charge 3
Boman Index 139
Hydrophobicity 46.97
Aliphatic Index 117.88
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 3.91
Polar residues 12
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23632907
Title Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata
Year 2013
Literature 2
Pubmed ID 17698251
Title Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii
Doi 10.1016/j.peptides.2007.07.002
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.