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Cr-AcACP1
General Information
DRACP ID DRACP00315
Peptide Name Cr-AcACP1
Sequence AWXLFDDGV
Sequence Length 9
UniProt ID B3EWE7
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides Induce apoptosis Proliferation inhibition
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HEp-2 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=0.8 mM | MTT assay | 72 h | 1 |
| HCT 15 | Colon adenocarcinoma | Carcinoma | IC50=1.0 mM | MTT assay | 72 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=1 mM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=4 mM
Target DNA
Affinity Not available
Mechanism Proapoptosis
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification X=Lys-Acetylation (Lysine with acetylation side group)
Chiral L
Physicochemical Information
Formula C44H57N9O12
Absent amino acids CEHIKMNPQRSTY
Common amino acids D
Mass 115688
Pl 3.49
Basic residues 0
Acidic residues 2
Hydrophobic residues 5
Net charge -2
Boman Index -42
Hydrophobicity 47.78
Aliphatic Index 86.67
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 687.5
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21882228
Title Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3239
This work is licensed under a Creative Commons Attribution 4.0 International License.