This work is licensed under a Creative Commons Attribution 4.0 International License.
Cr-ACP1
General Information
DRACP ID DRACP00316
Peptide Name Cr-ACP1
Sequence AWKLFDDGV
Sequence Length 9
UniProt ID B3EWE7
PubChem CID Not available
Origin Cycas revoluta seeds
Type Native peptide
Classification
Active ACP Cancer targeted peptides Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HEp-2 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1.5 mM | MTT assay | 72 h | 1 |
| HCT 15 | Colon adenocarcinoma | Carcinoma | IC50=0.8 mM | MTT assay | 72 h | 1 |
Hemolytic Activity Human erythrocytes: 5% Hemolysis=1 mM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>4 mM
Target DNA
Affinity Not available
Mechanism Proapoptosis
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C50H71N11O14
Absent amino acids CEHIMNPQRSTY
Common amino acids D
Mass 119307
Pl 4.11
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Net charge -1
Boman Index -597
Hydrophobicity 4.44
Aliphatic Index 86.67
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 687.5
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21882228
Title Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3238
This work is licensed under a Creative Commons Attribution 4.0 International License.