This work is licensed under a Creative Commons Attribution 4.0 International License.
p776
General Information
DRACP ID DRACP00317
Peptide Name p776
Sequence GVGSPYVSRLLGICL
Sequence Length 15
UniProt ID P04626 O18735 P06494 P70424
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Tumor cell line | Tumor | Carcinoma | Not available | ELISA assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Disrupting tumor-mediated mechanisms suppressing host immunity
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C69H116N18O19S
Absent amino acids ADEFHKMNQTW
Common amino acids GL
Mass 178375
Pl 8.53
Basic residues 1
Acidic residues 0
Hydrophobic residues 6
Net charge 1
Boman Index 1000
Hydrophobicity 110.67
Aliphatic Index 142.67
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 106.43
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21928125
Title Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.