This work is licensed under a Creative Commons Attribution 4.0 International License.
Cationic Amphiphilic
General Information
DRACP ID DRACP00320
Peptide Name Cationic Amphiphilic
Sequence GIIKKIIIKKIIIKKI
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=15 µM | WST-1 assay | Not available | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=25 µM | WST-1 assay | Not available | 1 |
Hemolytic Activity Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs
Normal (non-cancerous) Cytotoxicity NIH 3T3: low toxic
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H176N22O17
Absent amino acids ACDEFHLMNPQRSTVWY
Common amino acids I
Mass 213031
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 9
Net charge 6
Boman Index 1192
Hydrophobicity 104.38
Aliphatic Index 219.38
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21955251
Title Designed antimicrobial and antitumor peptides with high selectivity
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.