This work is licensed under a Creative Commons Attribution 4.0 International License.
Cationic Amphiphilic
General Information
DRACP ID DRACP00321
Peptide Name Cationic Amphiphilic
Sequence GIIKKIIIKKIIIKKIIIKKI
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=4 µM | WST-1 assay | Not available | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=10 µM | WST-1 assay | Not available | 1 |
Hemolytic Activity Human red blood cells: over the active concentration ranges against bacteria and cancer cells, there is little activity or toxicity against hRBCs
Normal (non-cancerous) Cytotoxicity NIH 3T3: low toxic
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C122H233N29O22
Absent amino acids ACDEFHLMNPQRSTVWY
Common amino acids I
Mass 281533
Pl 11.65
Basic residues 8
Acidic residues 0
Hydrophobic residues 12
Net charge 8
Boman Index 1558
Hydrophobicity 106.67
Aliphatic Index 222.86
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21955251
Title Designed antimicrobial and antitumor peptides with high selectivity
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.