Z1

General Information


DRACP ID  DRACP00331

Peptide Name   Z1

Sequence  KAAKKWAKAAKKAAKAWKKAA

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Meth A Mouse fibrosarcoma Sarcoma EC50>211 µM MTT assay Not available 1
MT-1 Human mammary carcinoma Carcinoma EC50=186 µM MTT assay Not available 1
HT-29 Colon adenocarcinoma Carcinoma EC50>211 µM MTT assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00331

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C106H180N32O22

Absent amino acids  CDEFGHILMNPQRSTVY

Common amino acids  A

Mass  261175

Pl  11.7

Basic residues  9

Acidic residues  0

Hydrophobic residues  12

Net charge  9

Boman Index  -2719

Hydrophobicity  -90

Aliphatic Index  47.62

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  550

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22057278

Title  Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity

Doi 10.1074/jbc.M111.279281

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.