This work is licensed under a Creative Commons Attribution 4.0 International License.
Z1
General Information
DRACP ID DRACP00331
Peptide Name Z1
Sequence KAAKKWAKAAKKAAKAWKKAA
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Meth A | Mouse fibrosarcoma | Sarcoma | EC50>211 µM | MTT assay | Not available | 1 |
| MT-1 | Human mammary carcinoma | Carcinoma | EC50=186 µM | MTT assay | Not available | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | EC50>211 µM | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C106H180N32O22
Absent amino acids CDEFGHILMNPQRSTVY
Common amino acids A
Mass 261175
Pl 11.7
Basic residues 9
Acidic residues 0
Hydrophobic residues 12
Net charge 9
Boman Index -2719
Hydrophobicity -90
Aliphatic Index 47.62
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 550
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22057278
Title Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.