This work is licensed under a Creative Commons Attribution 4.0 International License.
Peptide-1
General Information
DRACP ID DRACP00335
Peptide Name Peptide-1
Sequence IELLQARGGCX
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Coupling peptide
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=2.17 µM | MTT assay | 3 h | 1 |
| NCI-H358 | Minimally invasive lung adenocarcinoma | Carcinoma | IC50=4.63 mM | MTT assay | 3 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(11)=Pemetrexed
Chiral L
Physicochemical Information
Formula C44H76N14O13S
Absent amino acids DFHKMNPSTVWY
Common amino acids GL
Mass 132980
Pl 6.23
Basic residues 1
Acidic residues 1
Hydrophobic residues 4
Net charge 0
Boman Index -754
Hydrophobicity 37.27
Aliphatic Index 115.45
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22076954
Title New pemetrexed-peptide conjugates: synthesis, characterization and in vitro cytostatic effect on non-small cell lung carcinoma (NCI-H358) and human leukemia (HL-60) cells
Doi 10.1002/psc.1407
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.