This work is licensed under a Creative Commons Attribution 4.0 International License.
IL-4Rα-lytic peptide
General Information
DRACP ID DRACP00339
Peptide Name IL-4Rα-lytic peptide
Sequence KQLIRFLKRLDRNGGGKLlLKlLkkLLKlLKKK
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Interleukin-4 receptor a (IL-4Ra) chain
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BxPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=6.8 μmol/L | WST-1 assay | 24 h | 1 |
| SU.86.86 | Pancreatic adenocarcinoma | Carcinoma | IC50=7.5 μmol/L | WST-1 assay | 24 h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=13.2 μmol/L | WST-1 assay | 24 h | 1 |
| T98G | Glioblastoma | Blastoma | IC50=18.5 μmol/L | WST-1 assay | 24 h | 1 |
| A172 | Glioblastoma | Blastoma | IC50=6.8 μmol/L | WST-1 assay | 24 h | 1 |
| NCI-H322 | Minimally invasive lung adenocarcinoma | Carcinoma | IC50=3.6 μmol/L | WST-1 assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=5.7 μmol/L | WST-1 assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Targeting Interleukin-4 Receptor α
Affinity Not available
Mechanism The IL-4Rα–lytic peptide contains a target moiety to bind to IL-4Rα and a cellular toxic lytic peptide that selectively kills cancer cells
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C154H271N47O28
Absent amino acids ACEHMPSTVWY
Common amino acids L
Mass 380012
Pl 12.34
Basic residues 11
Acidic residues 1
Hydrophobic residues 11
Net charge 10
Boman Index -5506
Hydrophobicity -45.15
Aliphatic Index 118.18
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22084165
Title Targeting interleukin-4 receptor α with hybrid peptide for effective cancer therapy
Doi 10.1158/1535-7163.MCT-11-0363
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.