Peptide Libraray

MAC1

General Information

DRACP ID DRACP00344

Peptide Name MAC1

Sequence GFGMALKLLKKVL

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Macropins and their analogs

Type Synthetic peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=10±4 µM	MTT assay	48 h	1
SW480	Colon adenocarcinoma	Carcinoma	IC50=23±4 µM	MTT assay	48 h	1
CCRF-CEM	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	IC50=12±6 µM	MTT assay	48 h	1

Hemolytic Activity Human erythrocytes: IC50=165 μM

Normal (non-cancerous) Cytotoxicity HUVEC: IC50=28±6 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00344

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C68H120N16O14S

Absent amino acids CDEHINPQRSTWY

Common amino acids L

Mass 163210

Pl 11.1

Basic residues 3

Acidic residues 0

Hydrophobic residues 7

Net charge 3

Boman Index 1609

Hydrophobicity 103.08

Aliphatic Index 150

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22100226

Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

Doi 10.1016/j.peptides.2011.11.002

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available