This work is licensed under a Creative Commons Attribution 4.0 International License.
MAC1/4
General Information
DRACP ID DRACP00348
Peptide Name MAC1/4
Sequence GFGMaLKLLKKVL
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=15±5 µM | MTT assay | 48 h | 1 |
| SW480 | Colon adenocarcinoma | Carcinoma | IC50=49±9 µM | MTT assay | 48 h | 1 |
| CCRF-CEM | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=29 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: IC50>200 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=56±2 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification a=D-Ala
Chiral Mix
Physicochemical Information
Formula C65H113N15O12S
Absent amino acids ACDEHINPQRSTWY
Common amino acids L
Mass 154300
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 6
Net charge 3
Boman Index 1428
Hydrophobicity 89.23
Aliphatic Index 142.31
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22100226
Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Doi 10.1016/j.peptides.2011.11.002
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.