This work is licensed under a Creative Commons Attribution 4.0 International License.
MAC1/6
General Information
DRACP ID DRACP00349
Peptide Name MAC1/6
Sequence GfGMALKLLKKVL
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=8±2 µM | MTT assay | 48 h | 1 |
| SW480 | Colon adenocarcinoma | Carcinoma | IC50=29±3 µM | MTT assay | 48 h | 1 |
| CCRF-CEM | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=15 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: IC50=177 μM
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=21±5 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification f=D-Phe
Chiral Mix
Physicochemical Information
Formula C59H109N15O12S
Absent amino acids CDEFHINPQRSTWY
Common amino acids L
Mass 146691
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 6
Net charge 3
Boman Index 1311
Hydrophobicity 81.54
Aliphatic Index 150
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22100226
Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Doi 10.1016/j.peptides.2011.11.002
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.