Peptide Libraray

MAC1/9

General Information

DRACP ID DRACP00353

Peptide Name MAC1/9

Sequence GFKMALKLLKKVL

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=8±1 µM	MTT assay	48 h	1
SW480	Colon adenocarcinoma	Carcinoma	IC50=13±3 µM	MTT assay	48 h	1
CCRF-CEM	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	IC50=14±4 µM	MTT assay	48 h	1

Hemolytic Activity Human erythrocytes: IC50=199 μM

Normal (non-cancerous) Cytotoxicity HUVEC: IC50=17±2 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00353

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C72H129N17O14S

Absent amino acids CDEHINPQRSTWY

Common amino acids KL

Mass 170322

Pl 11.28

Basic residues 4

Acidic residues 0

Hydrophobic residues 7

Net charge 4

Boman Index 960

Hydrophobicity 76.15

Aliphatic Index 150

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22100226

Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

Doi 10.1016/j.peptides.2011.11.002

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available