Peptide Libraray

HAL-2/11

General Information

DRACP ID DRACP00358

Peptide Name HAL-2/11

Sequence GKWLSLLKHILK

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=14±3 µM	MTT assay	48 h	1
SW480	Colon adenocarcinoma	Carcinoma	IC50=40 µM	MTT assay	48 h	1
CCRF-CEM	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	Not available	MTT assay	48 h	1

Hemolytic Activity Rat erythrocytes: IC50=65 μM

Normal (non-cancerous) Cytotoxicity HUVEC: IC50=42±3 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00358

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C70H118N18O14

Absent amino acids ACDEFMNPQRTVY

Common amino acids L

Mass 163222

Pl 11.1

Basic residues 4

Acidic residues 0

Hydrophobic residues 6

Net charge 4

Boman Index 316

Hydrophobicity 22.5

Aliphatic Index 162.5

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 500

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22100226

Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

Doi 10.1016/j.peptides.2011.11.002

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available