Peptide Libraray

MAC2

General Information

DRACP ID DRACP00361

Peptide Name MAC2

Sequence GTGLPMSERRKIMLMMR

Sequence Length 17

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50> 100 µM	MTT assay	48 h	1
SW480	Colon adenocarcinoma	Carcinoma	IC50> 100 µM	MTT assay	48 h	1
CCRF-CEM	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	IC50=32 µM	MTT assay	48 h	1

Hemolytic Activity Human erythrocytes: IC50>200 μM

Normal (non-cancerous) Cytotoxicity HUVEC: IC50> 100 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00361

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C83H151N27O22S4

Absent amino acids ACDFHNQVWY

Common amino acids M

Mass 229308

Pl 12.22

Basic residues 4

Acidic residues 1

Hydrophobic residues 3

Net charge 3

Boman Index -3705

Hydrophobicity -30

Aliphatic Index 68.82

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 4

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22100226

Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

Doi 10.1016/j.peptides.2011.11.002

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available