Peptide Libraray

LL-III

General Information

DRACP ID DRACP00375

Peptide Name LL-III

Sequence VNWKKILGKIIKVVK

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Lasioglossin III and its analogs

Type Native peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=4±1 µM	MTT assay	48 h	1
SW480	Colon adenocarcinoma	Carcinoma	IC50=18±4 µM	MTT assay	48 h	1
CCRF-CEM	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Leukemia	IC50=5±3 µM	MTT assay	48 h	1

Hemolytic Activity Rat erythrocytes: IC50>200 μM

Normal (non-cancerous) Cytotoxicity HUVEC: IC50=15±4 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00375

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C86H152N22O17

Absent amino acids ACDEFHMPQRSTY

Common amino acids K

Mass 201620

Pl 11.4

Basic residues 5

Acidic residues 0

Hydrophobic residues 8

Net charge 5

Boman Index 68

Hydrophobicity 37.33

Aliphatic Index 162

Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 392.86

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22100226

Title Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells

Doi 10.1016/j.peptides.2011.11.002

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available