This work is licensed under a Creative Commons Attribution 4.0 International License.
Cathelicidin-1, CATH-1, Fowlicidin-1
General Information
DRACP ID DRACP00384
Peptide Name Cathelicidin-1, CATH-1, Fowlicidin-1
Sequence RVKRVWPLVIRTVIAGYNLYRAIKKK
Sequence Length 26
PubChem CID Not available
Origin Gallus gallus
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| RAW 264.7 | Mouse macrophage leukemia cell | Leukemia | 60% cell death=20 μM; 90% cell death=40 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 15.6% Hemolysis=4 µM; 23.1% Hemolysis=8 µM; 33.1% Hemolysis=16 µM; 43.6% Hemolysis=32 µM; 74.3% Hemolysis=64 µM; 87.4% Hemolysis=128 µM; Sheep erythrocytes: 10% Hemolysis=38 µM
Normal (non-cancerous) Cytotoxicity Madin-Darby canine kidney cells: 50% Cell death=15 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C148H250N44O31
Absent amino acids CDEFHMQS
Common amino acids KRV
Mass 358799
Pl 12.13
Basic residues 8
Acidic residues 0
Hydrophobic residues 12
Net charge 8
Boman Index -4372
Hydrophobicity -6.92
Aliphatic Index 127.31
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 8480
Absorbance 280nm 339.2
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20
Year 2019
Literature 2
Pubmed ID 16817888
Title Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken
Doi 10.1111/j.1742-4658.2006.05261.x
Year 2006
Literature 3
Pubmed ID 31473417
Title The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities
Doi 10.1016/j.ejmech.2019.111623
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_11
This work is licensed under a Creative Commons Attribution 4.0 International License.