This work is licensed under a Creative Commons Attribution 4.0 International License.
SVS-1
General Information
DRACP ID DRACP00391
Peptide Name SVS-1
Sequence KVKVKVKVpPTKVKVKVK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=4.9±0.6µM | MTT assay | 24h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=6.3±0.7µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=8.1±0.8µM | MTT assay | 24h | 1 |
| MDA-MB-436 | Invasive breast carcinoma of no special type | Carcinoma | IC50=5.6±0.5µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=80.8±12.8µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification p=D-Pro
Chiral Mix
Physicochemical Information
Formula C92H173N25O18
Absent amino acids ACDEFGHILMNQRSWY
Common amino acids K
Mass 222094
Pl 11.65
Basic residues 8
Acidic residues 0
Hydrophobic residues 7
Net charge 8
Boman Index -1869
Hydrophobicity -22.78
Aliphatic Index 112.78
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22413859
Title Anticancer ?-hairpin peptides: membrane-induced folding triggers activity
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.