This work is licensed under a Creative Commons Attribution 4.0 International License.
SVS-2
General Information
DRACP ID DRACP00392
Peptide Name SVS-2
Sequence kvkvkvkvPptkvkvkvk
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=3.2±0.6µM | MTT assay | 24h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=4.5±0.5µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=4.7±0.4µM | MTT assay | 24h | 1 |
| MDA-MB-436 | Invasive breast carcinoma of no special type | Carcinoma | IC50=3.2±0.4µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification k=D-Lys; v=D-Val; p=D-Pro; t=D-Thr
Chiral Mix
Physicochemical Information
Formula C5H-25NO-15
Absent amino acids ACDEFGHIKLMNQRSTVWY
Common amino acids P
Mass 11225
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index 0
Hydrophobicity -8.89
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22413859
Title Anticancer ?-hairpin peptides: membrane-induced folding triggers activity
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.