This work is licensed under a Creative Commons Attribution 4.0 International License.
Chassatide C8
General Information
DRACP ID DRACP00394
Peptide Name Chassatide C8
Sequence AIPCGESCVWIPCISTVIGCSCSNKVCYR
Sequence Length 29
UniProt ID I0B6F5
PubChem CID Not available
Origin Chassalia chartacea
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1 μM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: HD50=25.5 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys20; Cys8<--->Cys22; Cys13<--->Cys27
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C131H211N35O39S6
Absent amino acids DFHLMQ
Common amino acids C
Mass 359231
Pl 7.73
Basic residues 2
Acidic residues 1
Hydrophobic residues 9
Net charge 1
Boman Index -473
Hydrophobicity 75.52
Aliphatic Index 87.24
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 7365
Absorbance 280nm 263.04
Polar residues 15
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22467870
Title Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4287
This work is licensed under a Creative Commons Attribution 4.0 International License.