Chassatide C1

General Information


DRACP ID  DRACP00399

Peptide Name   Chassatide C1

Sequence  GDACGETCFTGICFTAGCSCNPWPTCTRN

Sequence Length  29

UniProt ID  C0HKH4 

PubChem CID  Not available

Origin  Chassalia chartacea

Type  Native peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=9.8μM MTT assay Not available 1

Hemolytic Activity  Human erythrocytes: HD50=51.9 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00399

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys4<--->Cys18; Cys8<--->Cys20; Cys13<--->Cys26; NCB: Gly1<--->Asn29

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C123H183N35O42S6

Absent amino acids  HKLMQVY

Common amino acids  C

Mass  351600

Pl  4.18

Basic residues  1

Acidic residues  2

Hydrophobic residues  6

Net charge  -1

Boman Index  -3171

Hydrophobicity  0.69

Aliphatic Index  20.34

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5875

Absorbance 280nm  209.82

Polar residues  18

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22467870

Title  Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities

Doi 10.1074/jbc.M111.338970

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_4282

DRACP is developed by Dr.Zheng's team.