This work is licensed under a Creative Commons Attribution 4.0 International License.
Chassatide C11
General Information
DRACP ID DRACP00400
Peptide Name Chassatide C11
Sequence IPCGESCVWIPCISGMFGCSCKDKVCYS
Sequence Length 28
UniProt ID C0HKH6
PubChem CID Not available
Origin Chassalia chartacea
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1.2 μM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: HD50=13.3 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys19; Cys7<--->Cys21; Cys12<--->Cys26
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H199N31O38S7
Absent amino acids AHLNQRT
Common amino acids C
Mass 349839
Pl 6.03
Basic residues 2
Acidic residues 2
Hydrophobic residues 7
Net charge 0
Boman Index 63
Hydrophobicity 60.71
Aliphatic Index 62.5
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 7365
Absorbance 280nm 272.78
Polar residues 14
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22467870
Title Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4289
This work is licensed under a Creative Commons Attribution 4.0 International License.