This work is licensed under a Creative Commons Attribution 4.0 International License.
Chassatide C11A
General Information
DRACP ID DRACP00401
Peptide Name Chassatide C11A
Sequence IPCGESCVWIPCISGXFGCSCKDKVCYS
Sequence Length 28
UniProt ID C0HKH6
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>15 μM | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: HD50>25 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys19; Cys7<--->Cys21; Cys12<--->Cys26
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=MetO (Methionine sulfoxide)
Chiral L
Physicochemical Information
Formula C124H188N30O36S6
Absent amino acids AHLMNQRT
Common amino acids C
Mass 345918
Pl 6.03
Basic residues 2
Acidic residues 2
Hydrophobic residues 7
Net charge 0
Boman Index -172
Hydrophobicity 53.93
Aliphatic Index 62.5
Half Life
/
Extinction Coefficient cystines 7365
Absorbance 280nm 272.78
Polar residues 14
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22467870
Title Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4290
This work is licensed under a Creative Commons Attribution 4.0 International License.