This work is licensed under a Creative Commons Attribution 4.0 International License.
P7
General Information
DRACP ID DRACP00403
Peptide Name P7
Sequence PLLQATLGGGS
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin No information found in the references
Type Native peptide
Classification
Active ACP Cancer targeted peptides Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | Carcinoma | IC50=1 µM | WST-1 assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Angiogenic factor FGF2
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiproliferative; Antiangiogenic
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C44H76N12O15
Absent amino acids CDEFHIKMNRVWY
Common amino acids GL
Mass 119172
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index 788
Hydrophobicity 49.09
Aliphatic Index 115.45
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22481251
Title The FGF2-binding peptide P7 inhibits melanoma growth in vitro and in vivo
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.