This work is licensed under a Creative Commons Attribution 4.0 International License.
GA-K3
General Information
DRACP ID DRACP00408
Peptide Name GA-K3
Sequence FLKWLFKWAKK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Brevinin-1EMa
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=41.21 µM | MTT assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=25.20 µM | MTT assay | 72 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=27.00 µM | MTT assay | 72 h | 1 |
| MKN45 | Gastric adenocarcinoma | Carcinoma | IC50=26.70 µM | MTT assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=47.69 µM | MTT assay | 72 h | 1 |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=27.39 µM | MTT assay | 72 h | 1 |
| SK-N-DZ | Neuroblastoma | Blastoma | IC50=24.76 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C79H115N17O12
Absent amino acids CDEGHIMNPQRSTVY
Common amino acids K
Mass 167344
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index 7
Hydrophobicity -21.82
Aliphatic Index 80
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1100
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22644847
Title Anticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.