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GA-W3
General Information
DRACP ID DRACP00409
Peptide Name GA-W3
Sequence FLGWLFKWAWK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Brevinin-1EMa
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=22.88 µM | MTT assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=20.36 µM | MTT assay | 72 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=24.63 µM | MTT assay | 72 h | 1 |
| MKN45 | Gastric adenocarcinoma | Carcinoma | IC50=24.31 µM | MTT assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=46.51 µM | MTT assay | 72 h | 1 |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=13.97 µM | MTT assay | 72 h | 1 |
| SK-N-DZ | Neuroblastoma | Blastoma | IC50=22.06 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C80H104N16O12
Absent amino acids CDEHIMNPQRSTVY
Common amino acids W
Mass 166036
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 1444
Hydrophobicity 37.27
Aliphatic Index 80
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 1650
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22644847
Title Anticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.