This work is licensed under a Creative Commons Attribution 4.0 International License.
GA-W4
General Information
DRACP ID DRACP00411
Peptide Name GA-W4
Sequence FLWWLFKWAWK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Brevinin-1EMa
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A498 | Renal cell carcinoma | Carcinoma | IC50=22.59 µM | MTT assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=15.88 µM | MTT assay | 72 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=14.80 µM | MTT assay | 72 h | 1 |
| MKN45 | Gastric adenocarcinoma | Carcinoma | IC50=13.77 µM | MTT assay | 72 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=24.32 µM | MTT assay | 72 h | 1 |
| SK-MEL-2 | Melanoma | Carcinoma | IC50=13.16 µM | MTT assay | 72 h | 1 |
| SK-N-DZ | Neuroblastoma | Blastoma | IC50=14.58 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C89H111N17O12
Absent amino acids CDEGHIMNPQRSTVY
Common amino acids W
Mass 178952
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 1583
Hydrophobicity 32.73
Aliphatic Index 80
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 2200
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22644847
Title Anticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.