This work is licensed under a Creative Commons Attribution 4.0 International License.
N29N
General Information
DRACP ID DRACP00413
Peptide Name N29N
Sequence PDEDAINNALNKVCSTGRRQRSICKQLLKK
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SW480 | Colon adenocarcinoma | Carcinoma | 100% cell viability at 5 µM | Cell Viability assay | 24 h | 1 |
| SW480 | Colon adenocarcinoma | Carcinoma | 40% cell viability at 50 µM | Cell Viability assay | 24 h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 100% cell viability at 5 µM | Cell Viability assay | 24 h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | <40% cell viability at 50 µM | Cell Viability assay | 24 h | 1 |
| SNU-1 | Gastric adenocarcinoma | Carcinoma | <100% cell viability at 5 µM | Cell Viability assay | 24 h | 1 |
| SNU-1 | Gastric adenocarcinoma | Carcinoma | <20% cell viability at 50 µM | Cell Viability assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Lyse cancer cells
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C141H248N48O45S2
Absent amino acids FHMWY
Common amino acids K
Mass 391740
Pl 10.34
Basic residues 7
Acidic residues 3
Hydrophobic residues 8
Net charge 4
Boman Index -9582
Hydrophobicity -94
Aliphatic Index 81.33
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 125
Absorbance 280nm 4.31
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22783018
Title Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.