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Peptide K14D
General Information
DRACP ID DRACP00414
Peptide Name Peptide K14D
Sequence KWKSFLKTFKSLKkTVLHTLLKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Acetylation
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1.52±0.05 µmol/L | MTS assay | 1 h | 1 |
Hemolytic Activity Human red blood cells: MHC=5.20±0.02 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral Mix
Physicochemical Information
Formula C139H228N34O32
Absent amino acids CDEGMNPQRY
Common amino acids K
Mass 333364
Pl 11.5
Basic residues 7
Acidic residues 0
Hydrophobic residues 11
Net charge 7
Boman Index -1561
Hydrophobicity 8.85
Aliphatic Index 105
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22837667
Title Role of helicity on the anticancer mechanism of action of cationic-helical peptides
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.