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Peptide K14D/K22D
General Information
DRACP ID DRACP00415
Peptide Name Peptide K14D/K22D
Sequence KWKSFLKTFKSLKkTVLHTLLkAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Acetylation
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=1.40±0.09 µmol/L | MTS assay | 1 h | 1 |
Hemolytic Activity Human red blood cells: MHC=20.81±0.06 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral Mix
Physicochemical Information
Formula C133H214N32O30
Absent amino acids CDEGMNPQRY
Common amino acids KL
Mass 318745
Pl 11.4
Basic residues 6
Acidic residues 0
Hydrophobic residues 11
Net charge 6
Boman Index -1006
Hydrophobicity 23.85
Aliphatic Index 105
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22837667
Title Role of helicity on the anticancer mechanism of action of cationic-helical peptides
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.