Peptide K3D/K7D /K10D/K14D/K22D

General Information


DRACP ID  DRACP00418

Peptide Name   Peptide K3D/K7D /K10D/K14D/K22D

Sequence  KWkSFLkTFkSLKkTVLHTLLkAISS

Sequence Length  26

UniProt ID  Not available

PubChem CID  Not available

Origin  Acetylation

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=20.41±0.64 µmol/L MTS assay 1 h 1

Hemolytic Activity  Human red blood cells: MHC> 325.20 μmol/L

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  Mix



Physicochemical Information


Formula  C115H172N26O24

Absent amino acids  CDEGMNPQRY

Common amino acids  L

Mass  274888

Pl  10.81

Basic residues  3

Acidic residues  0

Hydrophobic residues  11

Net charge  3

Boman Index  659

Hydrophobicity  68.85

Aliphatic Index  105

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  220

Polar residues  7

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22837667

Title  Role of helicity on the anticancer mechanism of action of cationic-helical peptides

Doi 10.3390/ijms13066849

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.